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Zeller Lab
Team
Research
Tools
Papers
Publications
Preprints
Machine learning inference of natural product chemistry across biosynthetic gene cluster types
Larralde M
,
Zeller G
,
biorxiv
(2025).
PyOrthoANI, PyFastANI, and Pyskani: a suite of Python libraries for computation of average nucleotide identity
Larralde M
,
Zeller G
,
Carroll LM
,
biorxiv
(2025).
Vigorous exercise associates with the abundance of gut bacterial species reflecting energy pathways: an epidemiological cross-sectional analysis within the Lifelines Dutch Microbiome Project
Morwani J, Ducarmon Q,
Zeller G
, Deelen J, Beekman M, Slagboom PE,
medrxiv
(2024).
Long-term fasting remodels gut microbial metabolism and host metabolism
Ducarmon QR
, Grundler F, Giannopoulou C, Loume A,
Karcher N
,
Larralde M
,
Romano SR
,
[...]
Mesnage R,
biorXiv
(2024).
Unraveling interindividual differences and functional consequences of gut microbial metabolism of immunosuppressants
Baghai Arassi M
,
Karcher N
, Mastrorilli E, Gross M, Brauer-Nikonow A,
Hackett R
, Czock D,
[...]
Zimmermann M,
biorXiv
(2024).
Secondary bile acid production by gut bacteria promotes Western diet-associated colorectal cancer
Wortmann E, Osswald A, Wylensek D, Kuhls S, Coleman OI,
Ducarmon QR
, Liang W,
[...]
Clavel T,
biorxiv
(2024).
Large-scale computational analyses of gut microbial CAZyme repertoires enabled by Cayman
Ducarmon QR
,
Karcher N
, Tytgat HLP, Delannoy-Bruno O,
Pekel S
,
Springer F
, Schudoma C,
Zeller G
,
biorxiv
(2024).
Machine learning-based meta-analysis reveals gut microbiome alterations associated with Parkinson’s disease
Romano S
,
Wirbel J
, Ansorge R, Schudoma C,
Ducarmon QR
, Narbad A,
Zeller G
,
bioRxiv
(2023).
ATF6 activation alters colonic lipid metabolism causing tumor-associated microbial adaptation
Coleman OI, Sorbie A, Bierwith S, Kövilein J, von Stern M, Köhler N,
Wirbel J
,
[...]
Haller D,
bioRxiv
(2023).
Accurate de novo identification of biosynthetic gene clusters with GECCO
Carroll LM
,
Larralde M
,
Fleck JS
,
Ponnudurai R
,
Milanese A
, Cappio E,
Zeller G
,
biorxiv
(2021).
2025
Heterologous Expression of a Cryptic BGC from Bilophila sp. Provides Access to a Novel Family of Antibacterial Thiazoles
Hohmann M, Iliasov D,
Larralde M
, Johannes W, Janssen KP,
Zeller G
, Mascher T, Gulder TAM,
ACS Synth Biol
(2025).
International consensus statement on microbiome testing in clinical practice
Porcari S, Mullish BH, Asnicar F, Ng SC, Zhao L, Hansen R, O'Toole PW,
[...]
Ianiro G,
Lancet Gastroenterol Hepatol
10 (2) :154-167 (2025).
Metagenomic global survey and in-depth genomic analyses of Ruminococcus gnavus reveal differences across host lifestyle and health status
Nooij S, Plomp N, Sanders IMJG, Schout L, van der Meulen AE, Terveer EM, Norman JM,
[...]
Ducarmon QR
,
Nat Commun
16 (1) :1182 (2025).
2024
The mOTUs online database provides web-accessible genomic context to taxonomic profiling of microbial communities
Dmitrijeva M, Ruscheweyh HJ, Feer L, Li K, Miravet-Verde S, Sintsova A, Mende DR,
[...]
Sunagawa S,
Nucleic Acids Res
(2024).
A realistic benchmark for differential abundance testing and confounder adjustment in human microbiome studies
Wirbel J
,
Essex M
, Forslund SK,
Zeller G
,
Genome Biol
25 (1) :247 (2024).
Profiling the fecal microbiome and its modulators across the lifespan in the Netherlands
Boverhoff D, Kool J, Pijnacker R,
Ducarmon QR
,
Zeller G
, Shetty S, Sie S,
[...]
Fuentes S,
Cell Rep
43 (9) :114729 (2024).
Bacillamide D produced by Bacillus cereus from the mouse intestinal bacterial collection (miBC) is a potent cytotoxin in vitro
Hohmann M, Brunner V, Johannes W, Schum D,
Carroll LM
, Liu T, Sasaki D,
[...]
Gulder TAM,
Commun Biol
7 (1) :655 (2024).
2023
High-throughput anaerobic screening for identifying compounds acting against gut bacteria in monocultures or communities
Müller P, de la Cuesta-Zuluaga J, Kuhn M,
Baghai Arassi M
, Treis T, Blasche S, Zimmermann M,
[...]
Maier L,
Nature Protocols
(2023).
Systematic analysis of drug combinations against Gram-positive bacteria
Cacace E, Kim V, Varik V, Knopp M, Tietgen M, Brauer-Nikonow A, Inecik K,
[...]
Typas A,
Nat Microbiol
8 (11) :2196-2212 (2023).
Remodelling of the intestinal ecosystem during caloric restriction and fasting
Ducarmon QR
, Grundler F, Le Maho Y, Wilhelmi de Toledo F,
Zeller G
, Habold C, Mesnage R,
Trends Microbiol
31 (8) :832-844 (2023).
C. difficile may be overdiagnosed in adults and is a prevalent commensal in infants
Ferretti P,
Wirbel J
, Maistrenk OM. Van Rossum T, Alves R, Fullam A, Akanni W, Schudoma C,
[...]
Bork P,
Elife
(2023).
PyHMMER: a Python library binding to HMMER for efficient sequence analysis
Larralde M
,
Zeller G
,
Bioinformatics
39 (5) (2023).
Location and condition based reconstruction of colon cancer microbiome from human RNA sequencing data
Sambruni G, Macandog AD,
Wirbel J
, Cagnina D, Catozzi C, Dallavilla T, Borgo F,
[...]
Schaefer MH,
Genome Med
15 (1) :32 (2023).
proGenomes3: approaching one million accurately and consistently annotated high-quality prokaryotic genomes
Fullam A, Letunic I, Schmidt TSB,
Ducarmon QR
,
Karcher N
, Khedkar S, Kuhn M,
[...]
Mende DR,
Nucleic Acids Res
51 (D1) :D760-D766 (2023).
2022
Cultivation-independent genomes greatly expand taxonomic-profiling capabilities of mOTUs across various environments
Ruscheweyh HJ,
Milanese A
, Paoli L,
Karcher N
, Clayssen Q, Keller MI,
Wirbel J
,
[...]
Sunagawa S,
Microbiome
10 (1) :212 (2022).
Depression and fatigue in active IBD from a microbiome perspective-a Bayesian approach to faecal metagenomics
Thomann AK, Wustenberg T,
Wirbel J
, Knoedler LL, Thomann PA,
Zeller G
, Ebert MP,
[...]
Reindl W,
BMC Med
20 (1) :366 (2022).
Bacterial retrons encode phage-defending tripartite toxin-antitoxin systems
Bobonis J, Mitosch K, Mateus A,
Karcher N
, Kritikos G, Selkrig J, Zietek M,
[...]
Typas A,
Nature
609 (7925) :144-150 (2022).
Biosynthetic potential of the global ocean microbiome
Paoli L, Ruscheweyh HJ, Forneris CC, Hubrich F, Kautsar S, Bhushan A, Lotti A,
[...]
Sunagawa S,
Nature
607 (7917) :111-118 (2022).
A faecal microbiota signature with high specificity for pancreatic cancer
Kartal E, Schmidt TSB, Molina-Montes E, Rodriguez-Perales S,
Wirbel J
, Maistrenko OM, Akanni WA,
[...]
Bork P,
Gut
71 (7) :1359-1372 (2022).
Pyrodigal: Python bindings and interface to Prodigal, an efficient method for gene prediction in prokaryotes
Larralde M
,
Journal of Open Source Software
(2022).
Critical Assessment of Metagenome Interpretation: the second round of challenges
Meyer F, Fritz A, Deng ZL, Koslicki D, Lesker TR, Gurevich A, Robertson G,
[...]
McHardy AC,
Nat Methods
19 (4) :429-440 (2022).
Microbiota-dependent activation of the myeloid calcineurin-NFAT pathway inhibits B7H3- and B7H4-dependent anti-tumor immunity in colorectal cancer
Peuker K, Strigli A, Tauriello DVF, Hendricks A, von Schonfels W, Burmeister G, Brosch M,
[...]
Zeissig S,
Immunity
55 (4) :701-717.e7 (2022).
Calorie restriction improves metabolic state independently of gut microbiome composition: a randomized dietary intervention trial
Sowah SA,
Milanese A
, Schubel R,
Wirbel J
, Kartal E, Johnson TS, Hirche F,
[...]
Zeller G
,
Genome Med
14 (1) :30 (2022).
Identifying temporal and spatial patterns of variation from multimodal data using MEFISTO
Velten B, Braunger JM, Argelaguet R, Arnol D,
Wirbel J
, Bredikhin D,
Zeller G
, Stegle O,
Nat Methods
19 (2) :179-186 (2022).
Association of intraindividual tacrolimus variability with de novo donor-specific HLA antibody development and allograft rejection in pediatric kidney transplant recipients with low immunological risk
Baghai Arassi M
, Gauche L, Schmidt J, Höcker B, Rieger S, Süsal C, Tönshoff B, Fichtner A,
Pediatric Nephrology
37 (10) :2503-2514 (2022).
2021
Reporting guidelines for human microbiome research: the STORMS checklist
Mirzayi C, Renson A, Zohra F, Elsafoury S, Geistlinger L, Kasselman LJ, Eckenrode K,
[...]
Waldron L,
Nat Med
27 (11) :1885-1892 (2021).
Unravelling the collateral damage of antibiotics on gut bacteria
Maier L, Goemans CV,
Wirbel J
, Kuhn M, Eberl C, Pruteanu M, Muller P,
[...]
Typas A,
Nature
599 (7883) :120-124 (2021).
Commensal Clostridiales strains mediate effective anti-cancer immune response against solid tumors
Montalban-Arques A, Katkeviciute E, Busenhart P, Bircher A,
Wirbel J
,
Zeller G
, Morsy Y,
[...]
Scharl M,
Cell Host Microbe
29 (10) :1573-1588.e7 (2021).
mOTUs: Profiling Taxonomic Composition, Transcriptional Activity and Strain Populations of Microbial Communities
Ruscheweyh HJ,
Milanese A
, Paoli L, Sintsova A, Mende DR,
Zeller G
, Sunagawa S,
Curr Protoc
1 (8) :e218 (2021).
Microbiome meta-analysis and cross-disease comparison enabled by the SIAMCAT machine learning toolbox
Wirbel J
, Zych K,
Essex M
,
Karcher N
, Kartal E, Salazar G, Bork P,
[...]
Zeller G
,
Genome Biol
22 (1) :93 (2021).
Metabolic cooperation and spatiotemporal niche partitioning in a kefir microbial community
Blasche S, Kim Y, Mars RAT, Machado D, Maansson M, Kafkia E,
Milanese A
,
[...]
Patil KR,
Nat Microbiol
6 (2) :196-208 (2021).
Statistical and Machine Learning Techniques in Human Microbiome Studies: Contemporary Challenges and Solutions
Moreno-Indias I, Lahti L, Nedyalkova M, Elbere I, Roshchupkin G, Adilovic M, Aydemir O,
[...]
Claesson MJ,
Front Microbiol
12 :635781 (2021).
2020
The gut microbiome in solid organ transplantation
Baghai Arassi M
,
Zeller G
,
Karcher N
, Zimmermann M, Toenshoff B,
Pediatr Transplant
24 (7) :e13866 (2020).
Analysis of 1321 Eubacterium rectale genomes from metagenomes uncovers complex phylogeographic population structure and subspecies functional adaptations
Karcher N
, Pasolli E, Asnicar F, Huang KD, Tett A, Manara S, Armanini F,
[...]
Segata N,
Genome Biol
21 (1) :138 (2020).
Changes in Plasma Short-Chain Fatty Acid Levels after Dietary Weight Loss Among Overweight and Obese Adults over 50 Weeks
Sowah SA, Hirche F,
Milanese A
, Johnson TS, Grafetstatter M, Schubel R, Kirsten R,
[...]
Stangl GI,
Nutrients
12 (2) (2020).
Metabolic models predict bacterial passengers in colorectal cancer
Garza DR, Taddese R,
Wirbel J
,
Zeller G
, Boleij A, Huynen MA, Dutilh BE,
Cancer Metab
8 :3 (2020).
proGenomes2: an improved database for accurate and consistent habitat, taxonomic and functional annotations of prokaryotic genomes
Mende DR, Letunic I, Maistrenko OM, Schmidt TSB,
Milanese A
, Paoli L, Hernandez-Plaza A,
[...]
Bork P,
Nucleic Acids Res
48 (D1) :D621-D625 (2020).
2019
Gene Expression Changes and Community Turnover Differentially Shape the Global Ocean Metatranscriptome
Salazar G, Paoli L, Alberti A, Huerta-Cepas J, Ruscheweyh HJ, Cuenca M, Field CM,
[...]
Sunagawa S,
Cell
179 (5) :1068-1083.e21 (2019).
Effects of Weight-Loss Interventions on Short-Chain Fatty Acid Concentrations in Blood and Feces of Adults: A Systematic Review
Sowah SA, Riedl L, Damms-Machado A, Johnson TS, Schubel R, Graf M, Kartal E,
[...]
Kuhn T,
Adv Nutr
10 (4) :673-684 (2019).
Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer
Wirbel J
, Pyl PT, Kartal E, Zych K, Kashani A,
Milanese A
,
Fleck JS
,
[...]
Zeller G
,
Nat Med
25 (4) :679-689 (2019).
Metagenomic analysis of colorectal cancer datasets identifies cross-cohort microbial diagnostic signatures and a link with choline degradation
Thomas AM, Manghi P, Asnicar F, Pasolli E, Armanini F, Zolfo M, Beghini F,
[...]
Segata N,
Nat Med
25 (4) :667-678 (2019).
Microbial abundance, activity and population genomic profiling with mOTUs2
Milanese A
, Mende DR, Paoli L, Salazar G, Ruscheweyh HJ, Cuenca M, Hingamp P,
[...]
Sunagawa S,
Nat Commun
10 (1) :1014 (2019).
Extensive transmission of microbes along the gastrointestinal tract
Schmidt TS, Hayward MR, Coelho LP, Li SS, Costea PI, Voigt AY,
Wirbel J
,
[...]
Bork P,
Elife
8 (2019).
2018
Nutritional preferences of human gut bacteria reveal their metabolic idiosyncrasies
Tramontano M, Andrejev S, Pruteanu M, Klunemann M, Kuhn M, Galardini M, Jouhten P,
[...]
Patil KR,
Nat Microbiol
3 (4) :514-522 (2018).
Extensive impact of non-antibiotic drugs on human gut bacteria
Maier L, Pruteanu M, Kuhn M,
Zeller G
, Telzerow A, Anderson EE, Brochado AR,
[...]
Typas A,
Nature
555 (7698) :623-628 (2018).
Enterotypes in the landscape of gut microbial community composition
Costea PI, Hildebrand F, Arumugam M, Backhed F, Blaser MJ, Bushman FD, de Vos WM,
[...]
Bork P,
Nat Microbiol
3 (1) :8-16 (2018).
2017
Subspecies in the global human gut microbiome
Costea PI, Coelho LP, Sunagawa S, Munch R, Huerta-Cepas J, Forslund K, Hildebrand F,
[...]
Bork P,
Mol Syst Biol
13 (12) :960 (2017).
Towards standards for human fecal sample processing in metagenomic studies
Costea PI,
Zeller G
, Sunagawa S, Pelletier E, Alberti A, Levenez F, Tramontano M,
[...]
Bork P,
Nat Biotechnol
35 (11) :1069-1076 (2017).
[Microbial Biomarkers for Early Cancer Detection]
Voigt AY,
Zeller G
, Bork P,
Dtsch Med Wochenschr
142 (4) :267-274 (2017).
2016
CART-a chemical annotation retrieval toolkit
Deghou S,
Zeller G
, Iskar M, Driessen M, Castillo M, van Noort V, Bork P,
Bioinformatics
32 (18) :2869-71 (2016).
MOCAT2: a metagenomic assembly, annotation and profiling framework
Kultima JR, Coelho LP, Forslund K, Huerta-Cepas J, Li SS, Driessen M, Voigt AY,
[...]
Bork P,
Bioinformatics
32 (16) :2520-3 (2016).
Durable coexistence of donor and recipient strains after fecal microbiota transplantation
Li SS, Zhu A, Benes V, Costea PI, Hercog R, Hildebrand F, Huerta-Cepas J,
[...]
Bork P,
Science
352 (6285) :586-9 (2016).
Gut Microbiota Linked to Sexual Preference and HIV Infection
Noguera-Julian M, Rocafort M, Guillen Y, Rivera J, Casadella M, Nowak P, Hildebrand F,
[...]
Paredes R,
EBioMedicine
5 :135-46 (2016).
Colorectal Cancer and the Human Gut Microbiome: Reproducibility with Whole-Genome Shotgun Sequencing
Vogtmann E, Hua X,
Zeller G
, Sunagawa S, Voigt AY, Hercog R, Goedert JJ,
[...]
Sinha R,
PLoS One
11 (5) :e0155362 (2016).
2015
Ocean plankton. Structure and function of the global ocean microbiome
Sunagawa S, Coelho LP, Chaffron S, Kultima JR, Labadie K, Salazar G, Djahanschiri B,
[...]
Bork P,
Science
348 (6237) :1261359 (2015).
Temporal and technical variability of human gut metagenomes
Voigt AY, Costea PI, Kultima JR, Li SS,
Zeller G
, Sunagawa S, Bork P,
Genome Biol
16 (1) :73 (2015).
2014
Potential of fecal microbiota for early-stage detection of colorectal cancer
Zeller G
, Tap J, Voigt AY, Sunagawa S, Kultima JR, Costea PI, Amiot A,
[...]
Bork P,
Mol Syst Biol
10 (11) :766 (2014).
Novel drug candidates for the treatment of metastatic colorectal cancer through global inverse gene-expression profiling
van Noort V, Scholch S, Iskar M,
Zeller G
, Ostertag K, Schweitzer C, Werner K,
[...]
Bork P,
Cancer Res
74 (20) :5690-9 (2014).
Oqtans: the RNA-seq workbench in the cloud for complete and reproducible quantitative transcriptome analysis
Sreedharan VT, Schultheiss SJ, Jean G, Kahles A, Bohnert R, Drewe P, Mudrakarta P,
[...]
Ratsch G,
Bioinformatics
30 (9) :1300-1 (2014).
2013
Metagenomic species profiling using universal phylogenetic marker genes
Sunagawa S, Mende DR,
Zeller G
, Izquierdo-Carrasco F, Berger SA, Kultima JR, Coelho LP,
[...]
Bork P,
Nat Methods
10 (12) :1196-9 (2013).
Accurate and universal delineation of prokaryotic species
Mende DR, Sunagawa S,
Zeller G
, Bork P,
Nat Methods
10 (9) :881-4 (2013).
Characterization of drug-induced transcriptional modules: towards drug repositioning and functional understanding
Iskar M,
Zeller G
, Blattmann P, Campillos M, Kuhn M, Kaminska KH, Runz H,
[...]
Bork P,
Mol Syst Biol
9 :662 (2013).
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